A.P. Bio Cast & Character Guide

The former NBC sitcom A.P. Bio has a robust cast full of hilarious main and supporting characters. Mike O’Brien of Saturday Night Live acclaim created the original sitcom, which first premiered on February 1, 2018. The show is centered around professor turned high-school teacher Jack Griffin, who is played by Glenn Howerton of It’s Always Sunny in Philadelphia. A.P. Bio follows Jack as he transitions from being a philosophy professor at Harvard University to an A.P. Biology teacher at his hometown high school after falling from grace due to a YouTube video.

A.P. Bio ran for two seasons on NBC before moving to Peacock for its final two seasons. The series was canceled twice even though it maintained an impressive Rotten Tomatoes score of 88%, with its second and third seasons earning perfect 100% critic scores. Despite the positive reviews of A.P. Bio, there was not enough consistent viewership for the series to continue past four seasons. Over its four-year span, A.P. Bio featured several notable guest stars and cameo appearances, making it one of the most unappreciated sitcoms in recent memory.

Glenn Howerton as Jack Griffin

Actor: Glenn Howerton, 48, is an American actor who was born in Japan. He is best known for playing Dennis Reynolds on the hit FX comedy series It’s Always Sunny In Philadelphia, which is the longest-running original comedy series in television history. Howeton co-created the series with co-star Rob McElhenney. Howerton made his film debut with 2005’s Must Love Dogs and has also appeared in films such as Crank, The Strangers, Everything Must Go, The Hunt, and Blackberry. Howerton’s other notable performances in television include That ’80s Show (2002), The Mindy Project (2012–2017), Fargo (2014), and Velma (2023-2024).

Notable Works:

Character: Howerton stars as the main character Dr. Jack Griffin in A.P. Bio.

Lyric Lewis as Stef Duncan

Actor: Lyric Lewis, 39, is an American actress and writer from New Orleans, Louisiana. Lewis is best known for Waffles + Mochi, Mad TV, and the Dreamworks series Curses! on Apple TV+. She has made guest appearances on several notable comedy series and sitcoms, including but not limited to Brooklyn Nine-Nine, Baskets, iCarly, Party Down, and Night Court. She has also made several appearances as herself on television shows such as Drunk History, Is It Cake?, and The Wheel. Lewis is expected to star in the upcoming short film I Am a Gigantosaurus, Actually alongside Alison Brie.

Notable Works:

Character: Lewis stars as the history teacher Stef Duncan in A.P. Bio.

Mary Sohn as Mary Wagner

Actor: Mary Sohn, 44, is an American actress from Illinois. Sohn is best known for her roles in The Boss, Between Two Ferns: The Movie, Love, Grace and Frankie, and Comedy Bang! Bang!. She recently appeared in an episode of Curb Your Enthusiasm and in the TBS series Miracle Workers. She rose to prominence after guest starring in an episode of the notable HBO comedy series Hello Ladies in 2013. She has also guest starred in episodes of Teachers, Superior Donuts, Shrink, and Bajillion Dollar Propertie$.

Notable Works:

Character: Sohn plays the art teacher Mary Wagner in A.P. Bio.

Jean Villepique as Michelle Jones

Actor: Jean Villepique is an American actress from New Jersey who attended Northwestern University. As a former member of The Second City, she is best known for her roles in BoJack Horseman and Up All Night. She made her television debut in 2007 in episodes of 30 Rock and Curb Your Enthusiasm. She also starred alongside Jason Segel and Paul Rudd in the 2009 comedy I Love You, Man. She has guest starred in many notable comedy series such as Modern Family, Workaholics, Grey’s Anatomy, Baskets, New Girl, and Better Call Saul. She is also known for playing Gretchen in Sharp Objects.

Notable Works:

Character: Villepique plays home ec teacher Michelle Jones in A.P. Bio.

Paula Pell as Helen Henry Demarcus

Actor: Paula Pell, 61, is an American comedy writer, producer, and actress from Illinois. Pell is a prolific writer for Saturday Night Live who has writing credits for more than 315 SNL episodes between 1995 and the present day. As an actress, Pell has appeared in Parks and Recreation, 30 Rock, Anchorman 2, Inside Out, The Mindy Project, Unbreakable Kimmy Schmidt, and Inside Out 2. She also voiced various roles in the Netflix animated series Big Mouth. She is slated to star alongside Matt Berry, Bill Hader, and Quinta Bronson in the upcoming The Cat in the Hat film as well as Summer of 69 with Chloe Fineman, Charlie Day, and Natalie Morales.

Notable Works:

Character: Pell plays school administrator Helen Henry Demarcus in A.P. Bio.

Patton Oswalt as Principal Ralph Durbin

Actor: Patton Oswalt, 55, is an American comedian and actor from Virginia who has more than 250 professional acting credits to his name. He is best known for his roles in Ratatouille, Young Adult, The Secret Life of Walter Mitty, and Seeking a Friend for the End of the World. He has recently appeared in Hacks, Manhunt, Ghostbusters: Frozen Empire, Family Guy, What We Do in the Shadows, and 80 for Brady. He is also an award-winning stand-up comedian who has been nominated for 4 Emmys with one win for Outstanding Writing for a Variety Special for 2016’s Talking for Clapping.

Notable Works:

Character: Oswalt plays Principal Ralph Durbin in A.P. Bio.

A.P. Bio Supporting Cast & Characters

Aparna Brielle as Sarika: Brielle is best known for FUBAR and Mech Cadets.

Nick Peine as Marcus: Peine is best known for Office Christmas Party and Just Getting Started.

Allisyn Snyder as Heather: Snyder is best known for Astrid Clover and Meet Dave.

Eddie Leavy as Anthony: Leavy is best known for Best. World. Weekend. Ever. and Those Who Can’t.

Jacob Houston as Victor: Houston is best known for Yellowjackets and L.A.’s Finest.

Sari Arambulo as Grace: Arambulo is best known for Alexa & Katie and Party of Five.

Spence Moore II as Dan Decker: Moore is best known for Creed III and We Are Who We Are.

Marisa Baram as Marissa: Baram is best known for Henry Danger and Real Husbands of Hollywood.

Miguel Lee as Eduardo: Lee is best known for Dave and The Saver.

Charlie McCrackin as Coach Dick Novak: McCracking is best known for Intergalactic Radio and Unstable.

A.P. Bio Cameo Guide

Nikki Glaser as Chloe from Baltimore: Glaser is best known for Trainwreck and The Roast of Tom Brady.

Niecy Nash as Kim Burke: Nash is best known for Reno 911! and Guess Who.

Taran Killam as Mr. Vining: Killam is best known for Saturday Night Live and 12 Years a Slave.

Mark Proksch as Philip: Proksch is best known for Better Call Saul and What We Do in the Shadows.

Christopher Lloyd as Melvin: Lloyd is best known for Back to the Future and The Addams Family.

Jon Lovitz as Robin Schwonk: Lovitz is best known for A League of Their Own and Rat Race.

Ron Funches as Hans: Funches is best known for Trolls and Inside Out 2.

Angela Kinsey as Brenda: Kinsey is best known for The Office and has a cameo in A.P. Bio.

A.P. Bio is an NBC comedy that premiered in 2018. The sitcom stars It’s Always Sunny in Philidelphia’s Glenn Howerton as Jack Griffin, a former philosophy professor who starts working as a high school advanced placement biology teacher. After season 2, A.P. Bio moved to Peacock for two seasons before getting canceled in 2021.

Cast

Glenn Howerton

Release Date

February 1, 2018

Seasons

4

Writers

Mike O’Brien

Directors

Mike O’Brien

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